Independent rediploidization masks shared whole genome duplication in the sturgeon-paddlefish ancestor

Anthony K. Redmond, Dearbhaile Casey, Manu Kumar Gundappa, Daniel J. Macqueen and Aoife McLysaght ()
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Anthony K. Redmond: Smurfit Institute of Genetics, Trinity College Dublin
Dearbhaile Casey: Smurfit Institute of Genetics, Trinity College Dublin
Manu Kumar Gundappa: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
Daniel J. Macqueen: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
Aoife McLysaght: Smurfit Institute of Genetics, Trinity College Dublin

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Whole genome duplication (WGD) is a dramatic evolutionary event generating many new genes and which may play a role in survival through mass extinctions. Paddlefish and sturgeon are sister lineages that both show genomic evidence for ancient WGD. Until now this has been interpreted as two independent WGD events due to a preponderance of duplicate genes with independent histories. Here we show that although there is indeed a plurality of apparently independent gene duplications, these derive from a shared genome duplication event occurring well over 200 million years ago, likely close to the Permian-Triassic mass extinction period. This was followed by a prolonged process of reversion to stable diploid inheritance (rediploidization), that may have promoted survival during the Triassic-Jurassic mass extinction. We show that the sharing of this WGD is masked by the fact that paddlefish and sturgeon lineage divergence occurred before rediploidization had proceeded even half-way. Thus, for most genes the resolution to diploidy was lineage-specific. Because genes are only truly duplicated once diploid inheritance is established, the paddlefish and sturgeon genomes are thus a mosaic of shared and non-shared gene duplications resulting from a shared genome duplication event.

Date: 2023
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DOI: 10.1038/s41467-023-38714-z

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