Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy

Dongdong Wang, Jiawei Liu, Changlai Wang, Weiyun Zhang, Guangbao Yang, Yun Chen, Xiaodong Zhang, Yinglong Wu, Long Gu, Hongzhong Chen, Wei Yuan, Xiaokai Chen, Guofeng Liu, Bin Gao, Qianwang Chen and Yanli Zhao ()
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Dongdong Wang: Nanyang Technological University
Jiawei Liu: Nanyang Technological University
Changlai Wang: University of Science and Technology of China
Weiyun Zhang: Shenzhen University
Guangbao Yang: Nanyang Technological University
Yun Chen: Nanyang Technological University
Xiaodong Zhang: Nanyang Technological University
Yinglong Wu: Nanyang Technological University
Long Gu: Nanyang Technological University
Hongzhong Chen: Nanyang Technological University
Wei Yuan: Nanyang Technological University
Xiaokai Chen: Nanyang Technological University
Guofeng Liu: Nanyang Technological University
Bin Gao: Nanyang Technological University
Qianwang Chen: University of Science and Technology of China
Yanli Zhao: Nanyang Technological University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Cancer immunotherapy is revolutionizing oncology. The marriage of nanotechnology and immunotherapy offers a great opportunity to amplify antitumor immune response in a safe and effective manner. Here, electrochemically active Shewanella oneidensis MR-1 can be applied to produce FDA-approved Prussian blue nanoparticles on a large-scale. We present a mitochondria-targeting nanoplatform, MiBaMc, which consists of Prussian blue decorated bacteria membrane fragments having further modifications with chlorin e6 and triphenylphosphine. We find that MiBaMc specifically targets mitochondria and induces amplified photo-damages and immunogenic cell death of tumor cells under light irradiation. The released tumor antigens subsequently promote the maturation of dendritic cells in tumor-draining lymph nodes, eliciting T cell-mediated immune response. In two tumor-bearing mouse models using female mice, MiBaMc triggered phototherapy synergizes with anti-PDL1 blocking antibody for enhanced tumor inhibition. Collectively, the present study demonstrates biological precipitation synthetic strategy of targeted nanoparticles holds great potential for the preparation of microbial membrane-based nanoplatforms to boost antitumor immunity.

Date: 2023
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DOI: 10.1038/s41467-023-38796-9

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