Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade

Juan Carlos Yam-Puc (), Zhaleh Hosseini, Emily C. Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O’Reilly, Harry Robson, Lucy H. Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie Kingston, Thomas E. Mulroney, Lucia P. G. Piñon, Michael A. Chapman, Sofia Grigoriadou, Marion MacFarlane, Anne E. Willis, Kiran R. Patil, Sarah Spencer, Emily Staples, Klaus Warnatz, Matthew S. Buckland, Florian Hollfelder, Marko Hyvönen, Rainer Döffinger, Christine Parkinson, Sara Lear, Nicholas J. Matheson and James E. D. Thaventhiran ()
Additional contact information
Juan Carlos Yam-Puc: University of Cambridge
Zhaleh Hosseini: University of Cambridge
Emily C. Horner: University of Cambridge
Pehuén Pereyra Gerber: University of Cambridge
Nonantzin Beristain-Covarrubias: University of Cambridge
Robert Hughes: University of Cambridge
Aleksei Lulla: University of Cambridge
Maria Rust: University of Cambridge
Rebecca Boston: University of Cambridge
Magda Ali: University of Cambridge
Katrin Fischer: University of Cambridge
Edward Simmons-Rosello: University of Cambridge
Martin O’Reilly: University of Cambridge
Harry Robson: University of Cambridge
Lucy H. Booth: University of Cambridge
Lakmini Kahanawita: University of Cambridge
Andrea Correa-Noguera: Cambridge University NHS Hospitals Foundation Trust
David Favara: Cambridge University NHS Hospitals Foundation Trust
Lourdes Ceron-Gutierrez: Cambridge University NHS Hospitals Foundation Trust
Baerbel Keller: University of Freiburg
Andrew Craxton: University of Cambridge
Georgina S. F. Anderson: University of Cambridge
Xiao-Ming Sun: University of Cambridge
Anne Elmer: NIHR Cambridge Clinical Research Facility
Caroline Saunders: NIHR Cambridge Clinical Research Facility
Areti Bermperi: NIHR Cambridge Clinical Research Facility
Sherly Jose: NIHR Cambridge Clinical Research Facility
Nathalie Kingston: Cambridge University Hospitals NHS Foundation Trust
Thomas E. Mulroney: University of Cambridge
Lucia P. G. Piñon: University of Cambridge
Michael A. Chapman: University of Cambridge
Sofia Grigoriadou: Barts Health
Marion MacFarlane: University of Cambridge
Anne E. Willis: University of Cambridge
Kiran R. Patil: University of Cambridge
Sarah Spencer: University of Cambridge
Emily Staples: University of Cambridge
Klaus Warnatz: University of Freiburg
Matthew S. Buckland: Barts Health
Florian Hollfelder: University of Cambridge
Marko Hyvönen: University of Cambridge
Rainer Döffinger: Cambridge University NHS Hospitals Foundation Trust
Christine Parkinson: Cambridge University NHS Hospitals Foundation Trust
Sara Lear: Cambridge University NHS Hospitals Foundation Trust
Nicholas J. Matheson: University of Cambridge
James E. D. Thaventhiran: University of Cambridge

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whether ABCs from different conditions are similar and how they impact the longitudinal level of the COVID-19 vaccine response. Single-cell RNA sequencing indicates that ABCs with distinct aetiologies have common transcriptional profiles and can be categorised according to their expression of immune genes, such as the autoimmune regulator (AIRE). Furthermore, higher baseline ABC frequency correlates with decreased levels of antigen-specific memory B cells and reduced neutralising capacity against SARS-CoV-2. ABCs express high levels of the inhibitory FcγRIIB receptor and are distinctive in their ability to bind immune complexes, which could contribute to diminish vaccine responses either directly, or indirectly via enhanced clearance of immune complexed-antigen. Expansion of ABCs may, therefore, serve as a biomarker identifying individuals at risk of suboptimal responses to vaccination.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-38810-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38810-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-38810-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().