Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

Stefano Garofalo (), Germana Cocozza, Alessandro Mormino, Giovanni Bernardini, Eleonora Russo, Donald Ielpo, Diego Andolina, Rossella Ventura, Katiuscia Martinello, Massimiliano Renzi, Sergio Fucile, Mattia Laffranchi, Eva Piano Mortari, Rita Carsetti, Giuseppe Sciumè, Silvano Sozzani, Angela Santoni, Marie-Eve Tremblay, Richard M. Ransohoff and Cristina Limatola ()
Additional contact information
Stefano Garofalo: Sapienza University of Rome
Germana Cocozza: Sapienza University of Rome
Alessandro Mormino: Sapienza University of Rome
Giovanni Bernardini: Sapienza University of Rome
Eleonora Russo: Sapienza University of Rome
Donald Ielpo: Sapienza University of Rome
Diego Andolina: Sapienza University of Rome
Rossella Ventura: Sapienza University of Rome
Katiuscia Martinello: IRCCS Neuromed
Massimiliano Renzi: Sapienza University of Rome
Sergio Fucile: Sapienza University of Rome
Mattia Laffranchi: Sapienza University of Rome
Eva Piano Mortari: Bambino Gesù Children’s Hospital, IRCCS
Rita Carsetti: Bambino Gesù Children’s Hospital, IRCCS
Giuseppe Sciumè: Sapienza University of Rome
Silvano Sozzani: IRCCS Neuromed
Angela Santoni: IRCCS Neuromed
Marie-Eve Tremblay: Centre de Recherche CHU de Quebec-Université Laval
Richard M. Ransohoff: Third Rock Ventures
Cristina Limatola: IRCCS Neuromed

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38899-3

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DOI: 10.1038/s41467-023-38899-3

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