Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics

Hiroaki Kikuchi (), Chung-Lin Chou, Chin-Rang Yang, Lihe Chen, Hyun Jun Jung, Euijung Park, Kavee Limbutara, Benjamin Carter, Zhi-Hong Yang, Julia F. Kun, Alan T. Remaley and Mark A. Knepper ()
Additional contact information
Hiroaki Kikuchi: National Institutes of Health
Chung-Lin Chou: National Institutes of Health
Chin-Rang Yang: National Institutes of Health
Lihe Chen: National Institutes of Health
Hyun Jun Jung: Johns Hopkins University School of Medicine
Euijung Park: National Institutes of Health
Kavee Limbutara: Chulalongkorn University
Benjamin Carter: Lung and Blood Institute, NIH
Zhi-Hong Yang: National Institutes of Health
Julia F. Kun: National Institutes of Health
Alan T. Remaley: National Institutes of Health
Mark A. Knepper: National Institutes of Health

Nature Communications, 2023, vol. 14, issue 1, 1-22

Abstract: Abstract Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38958-9

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DOI: 10.1038/s41467-023-38958-9

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