Circadian regulation of developmental synaptogenesis via the hypocretinergic system

Xu-Fei Du (), Fu-Ning Li, Xiao-Lan Peng, Bing Xu, Yu Zhang, Guang Li, Taole Liu, Ying Li, Han Wang, Jun Yan and Jiu-Lin Du ()
Additional contact information
Xu-Fei Du: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Fu-Ning Li: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Xiao-Lan Peng: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Bing Xu: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Yu Zhang: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Guang Li: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Taole Liu: Soochow University
Ying Li: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Han Wang: Soochow University
Jun Yan: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Jiu-Lin Du: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt to daily environmental changes, particularly the day-night cycle. However, the circadian clock’s role in the developmental processes remains unclear. Here, we employ the in vivo long-term time-lapse imaging of retinotectal synapses in the optic tectum of larval zebrafish and reveal that synaptogenesis, a fundamental developmental process for neural circuit formation, exhibits circadian rhythm. This rhythmicity arises primarily from the synapse formation rather than elimination and requires the hypocretinergic neural system. Disruption of this synaptogenic rhythm, by impairing either the circadian clock or the hypocretinergic system, affects the arrangement of the retinotectal synapses on axon arbors and the refinement of the postsynaptic tectal neuron’s receptive field. Thus, our findings demonstrate that the developmental synaptogenesis is under hypocretin-dependent circadian regulation, suggesting an important role of the circadian clock in neural development.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-38973-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38973-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-38973-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().