Multiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell

Lisa T. Pulianmackal, Jose Miguel I. Limcaoco, Keerthikka Ravi, Sinyu Yang, Jeffrey Zhang, Mimi K. Tran, Maria Ghalmi, Matthew J. O’Meara and Anthony G. Vecchiarelli ()
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Lisa T. Pulianmackal: University of Michigan
Jose Miguel I. Limcaoco: University of Michigan
Keerthikka Ravi: University of Michigan
Sinyu Yang: University of Michigan
Jeffrey Zhang: University of Michigan
Mimi K. Tran: University of Michigan
Maria Ghalmi: University of Michigan
Matthew J. O’Meara: University of Michigan
Anthony G. Vecchiarelli: University of Michigan

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract In eukaryotes, linear motor proteins govern intracellular transport and organization. In bacteria, where linear motors involved in spatial regulation are absent, the ParA/MinD family of ATPases organize an array of genetic- and protein-based cellular cargos. The positioning of these cargos has been independently investigated to varying degrees in several bacterial species. However, it remains unclear how multiple ParA/MinD ATPases can coordinate the positioning of diverse cargos in the same cell. Here, we find that over a third of sequenced bacterial genomes encode multiple ParA/MinD ATPases. We identify an organism (Halothiobacillus neapolitanus) with seven ParA/MinD ATPases, demonstrate that five of these are each dedicated to the spatial regulation of a single cellular cargo, and define potential specificity determinants for each system. Furthermore, we show how these positioning reactions can influence each other, stressing the importance of understanding how organelle trafficking, chromosome segregation, and cell division are coordinated in bacterial cells. Together, our data show how multiple ParA/MinD ATPases coexist and function to position a diverse set of fundamental cargos in the same bacterial cell.

Date: 2023
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DOI: 10.1038/s41467-023-39019-x

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