Intracranial electrophysiological and structural basis of BOLD functional connectivity in human brain white matter

Yali Huang, Peng-Hu Wei, Longzhou Xu, Desheng Chen, Yanfeng Yang, Wenkai Song, Yangyang Yi, Xiaoli Jia, Guowei Wu, Qingchen Fan, Zaixu Cui () and Guoguang Zhao ()
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Yali Huang: Chinese Institute for Brain Research
Peng-Hu Wei: Xuanwu Hospital Capital Medical University
Longzhou Xu: Chinese Institute for Brain Research
Desheng Chen: Xuanwu Hospital Capital Medical University
Yanfeng Yang: Xuanwu Hospital Capital Medical University
Wenkai Song: Chinese Institute for Brain Research
Yangyang Yi: Chinese Institute for Brain Research
Xiaoli Jia: Chinese Institute for Brain Research
Guowei Wu: Chinese Institute for Brain Research
Qingchen Fan: Chinese Institute for Brain Research
Zaixu Cui: Chinese Institute for Brain Research
Guoguang Zhao: Xuanwu Hospital Capital Medical University

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract While functional MRI (fMRI) studies have mainly focused on gray matter, recent studies have consistently found that blood-oxygenation-level-dependent (BOLD) signals can be reliably detected in white matter, and functional connectivity (FC) has been organized into distributed networks in white matter. Nevertheless, it remains unclear whether this white matter FC reflects underlying electrophysiological synchronization. To address this question, we employ intracranial stereotactic-electroencephalography (SEEG) and resting-state fMRI data from a group of 16 patients with drug-resistant epilepsy. We find that BOLD FC is correlated with SEEG FC in white matter, and this result is consistent across a wide range of frequency bands for each participant. By including diffusion spectrum imaging data, we also find that white matter FC from both SEEG and fMRI are correlated with white matter structural connectivity, suggesting that anatomical fiber tracts underlie the functional synchronization in white matter. These results provide evidence for the electrophysiological and structural basis of white matter BOLD FC, which could be a potential biomarker for psychiatric and neurological disorders.

Date: 2023
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DOI: 10.1038/s41467-023-39067-3

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