Deep optoacoustic localization microangiography of ischemic stroke in mice

Xosé Luís Deán-Ben (), Justine Robin, Daniil Nozdriukhin, Ruiqing Ni, Jim Zhao, Chaim Glück, Jeanne Droux, Juan Sendón-Lago, Zhenyue Chen, Quanyu Zhou, Bruno Weber, Susanne Wegener, Anxo Vidal, Michael Arand, Mohamad El Amki and Daniel Razansky ()
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Xosé Luís Deán-Ben: University of Zurich
Justine Robin: University of Zurich
Daniil Nozdriukhin: University of Zurich
Ruiqing Ni: University of Zurich
Jim Zhao: University of Zurich
Chaim Glück: Institute of Pharmacology and Toxicology, University of Zurich, and Zurich Neuroscience Center
Jeanne Droux: Zurich Neuroscience Center
Juan Sendón-Lago: University of Santiago de Compostela
Zhenyue Chen: University of Zurich
Quanyu Zhou: University of Zurich
Bruno Weber: Institute of Pharmacology and Toxicology, University of Zurich, and Zurich Neuroscience Center
Susanne Wegener: Zurich Neuroscience Center
Anxo Vidal: University of Santiago de Compostela
Michael Arand: University of Zurich
Mohamad El Amki: Zurich Neuroscience Center
Daniel Razansky: University of Zurich

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible dichloromethane-based microdroplets exhibiting several orders of magnitude higher optical absorption than red blood cells at near-infrared wavelengths, thus enabling single-particle detection in vivo. We demonstrate non-invasive three-dimensional microangiography of the mouse brain beyond the acoustic diffraction limit (

Date: 2023
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DOI: 10.1038/s41467-023-39069-1

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