Scarless wound healing programmed by core-shell microneedles

Ying Zhang, Shenqiang Wang (), Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang () and Zhen Gu ()
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Ying Zhang: Zhejiang University
Shenqiang Wang: Zhejiang University
Yinxian Yang: Zhejiang University
Sheng Zhao: Zhejiang University
Jiahuan You: Zhejiang University
Junxia Wang: Zhejiang University
Jingwei Cai: Zhejiang University
Hao Wang: Zhejiang University
Jie Wang: Zhejiang University
Wei Zhang: Zhejiang University
Jicheng Yu: Zhejiang University
Chunmao Han: Zhejiang University
Yuqi Zhang: Zhejiang University
Zhen Gu: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models.

Date: 2023
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DOI: 10.1038/s41467-023-39129-6

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