Augmented temperature fluctuation aggravates muscular atrophy through the gut microbiota

Ya Liu, Yifan Guo, Zheyu Liu, Xu Feng, Rui Zhou, Yue He, Haiyan Zhou, Hui Peng and Yan Huang ()
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Ya Liu: Xiangya Hospital of Central South University
Yifan Guo: Xiangya Hospital of Central South University
Zheyu Liu: Xiangya Hospital of Central South University
Xu Feng: Xiangya Hospital of Central South University
Rui Zhou: Xiangya Hospital of Central South University
Yue He: Xiangya Hospital of Central South University
Haiyan Zhou: Xiangya Hospital of Central South University
Hui Peng: Xiangya Hospital of Central South University
Yan Huang: Xiangya Hospital of Central South University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Large temperature difference is reported to be a risk factor for human health. However, little evidence has reported the effects of temperature fluctuation on sarcopenia, a senile disease characterized by loss of muscle mass and function. Here, we demonstrate that higher diurnal temperature range in humans has a positive correlation with the prevalence of sarcopenia. Fluctuated temperature exposure (10–25 °C) accelerates muscle atrophy and dampens exercise performance in mid-aged male mice. Interestingly, fluctuated temperature alters the microbiota composition with increased levels of Parabacteroides_distasonis, Duncaniella_dubosii and decreased levels of Candidatus_Amulumruptor, Roseburia, Eubacterium. Transplantation of fluctuated temperature-shaped microbiota replays the adverse effects on muscle function. Mechanically, we find that altered microbiota increases circulating aminoadipic acid, a lysine degradation product. Aminoadipic acid damages mitochondrial function through inhibiting mitophagy in vitro. And Eubacterium supplementation alleviates muscle atrophy and dysfunction induced by fluctuated temperature. Our results uncover the detrimental impact of fluctuated temperature on muscle function and provide a new clue for gut-muscle axis.

Date: 2023
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DOI: 10.1038/s41467-023-39171-4

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