Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Daniel H. Daneshvar (), Evan S. Nair, Zachary H. Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Christine M. Baugh, Brett M. Martin, Joseph N. Palmisano, Jonathan D. Cherry, Victor E. Alvarez, Bertrand R. Huber, Jennifer Weuve, Christopher J. Nowinski, Robert C. Cantu, Ross D. Zafonte, Brigid Dwyer, John F. Crary, Lee E. Goldstein, Neil W. Kowall, Douglas I. Katz, Robert A. Stern, Yorghos Tripodis, Thor D. Stein, Michael D. McClean, Michael L. Alosco, Ann C. McKee and Jesse Mez
Additional contact information
Daniel H. Daneshvar: Harvard Medical School
Evan S. Nair: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Zachary H. Baucom: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Abigail Rasch: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Bobak Abdolmohammadi: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Madeline Uretsky: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Nicole Saltiel: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Arsal Shah: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Johnny Jarnagin: Harvard Medical School
Christine M. Baugh: University of Colorado Denver Anschutz Medical Campus
Brett M. Martin: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Joseph N. Palmisano: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Jonathan D. Cherry: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Victor E. Alvarez: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Bertrand R. Huber: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Jennifer Weuve: Boston University School of Public Health
Christopher J. Nowinski: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Robert C. Cantu: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Ross D. Zafonte: Harvard Medical School
Brigid Dwyer: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
John F. Crary: Icahn School of Medicine at Mount Sinai
Lee E. Goldstein: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Neil W. Kowall: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Douglas I. Katz: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Robert A. Stern: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Yorghos Tripodis: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Thor D. Stein: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Michael D. McClean: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Michael L. Alosco: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Ann C. McKee: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine
Jesse Mez: Boston University Alzheimer’s Disease Research and CTE Centers, Boston University Chobanian & Avedisian School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear. We create a position exposure matrix (PEM), composed of American football helmet sensor data, summarized from literature review by player position and level of play. Using this PEM, we estimate measures of lifetime RHI exposure for a separate cohort of 631 football playing brain donors. Separate models examine the relationship between CTE pathology and players’ concussion count, athletic positions, years of football, and PEM-derived measures, including estimated cumulative head impacts, linear accelerations, and rotational accelerations. Only duration of play and PEM-derived measures are significantly associated with CTE pathology. Models incorporating cumulative linear or rotational acceleration have better model fit and are better predictors of CTE pathology than duration of play or cumulative head impacts alone. These findings implicate cumulative head impact intensity in CTE pathogenesis.

Date: 2023
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DOI: 10.1038/s41467-023-39183-0

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