Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Kwasi Adu-Berchie, Joshua M. Brockman, Yutong Liu, Tania W. To, David K. Y. Zhang, Alexander J. Najibi, Yoav Binenbaum, Alexander Stafford, Nikolaos Dimitrakakis, Miguel C. Sobral, Maxence O. Dellacherie and David J. Mooney ()
Additional contact information
Kwasi Adu-Berchie: Harvard University
Joshua M. Brockman: Harvard University
Yutong Liu: Harvard University
Tania W. To: The Wyss Institute for Biologically Inspired Engineering Harvard University
David K. Y. Zhang: Harvard University
Alexander J. Najibi: Harvard University
Yoav Binenbaum: The Wyss Institute for Biologically Inspired Engineering Harvard University
Alexander Stafford: The Wyss Institute for Biologically Inspired Engineering Harvard University
Nikolaos Dimitrakakis: The Wyss Institute for Biologically Inspired Engineering Harvard University
Miguel C. Sobral: Harvard University
Maxence O. Dellacherie: Harvard University
David J. Mooney: Harvard University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Although adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a hydrogel that locally delivers adoptively transferred T cells to the tumor site while recruiting and activating host antigen-presenting cells with GMCSF or FLT3L and CpG, respectively. T cells alone loaded into these localized cell depots provided significantly better control of subcutaneous B16-F10 tumors than T cells delivered through direct peritumoral injection or intravenous infusion. T cell delivery combined with biomaterial-driven accumulation and activation of host immune cells prolonged the activation of the delivered T cells, minimized host T cell exhaustion, and enabled long-term tumor control. These findings highlight how this integrated approach provide both immediate tumor debulking and long-term protection against solid tumors, including against tumor antigen escape.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-39330-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39330-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-39330-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().