Gut microbiota Turicibacter strains differentially modify bile acids and host lipids

Jonathan B. Lynch (), Erika L. Gonzalez, Kayli Choy, Kym F. Faull, Talia Jewell, Abelardo Arellano, Jennifer Liang, Kristie B. Yu, Jorge Paramo and Elaine Y. Hsiao
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Jonathan B. Lynch: University of California, Los Angeles
Erika L. Gonzalez: University of California, Los Angeles
Kayli Choy: University of California, Los Angeles
Kym F. Faull: University of California, Los Angeles
Talia Jewell: Isolation Bio
Abelardo Arellano: Isolation Bio
Jennifer Liang: Isolation Bio
Kristie B. Yu: University of California, Los Angeles
Jorge Paramo: University of California, Los Angeles
Elaine Y. Hsiao: University of California, Los Angeles

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and correlate with alterations in dietary fat and body weight, but the specific connections between these symbionts and host physiology are poorly understood. To address this knowledge gap, we characterize a diverse set of mouse- and human-derived Turicibacter isolates, and find they group into clades that differ in their transformations of specific bile acids. We identify Turicibacter bile salt hydrolases that confer strain-specific differences in bile deconjugation. Using male and female gnotobiotic mice, we find colonization with individual Turicibacter strains leads to changes in host bile acid profiles, generally aligning with those produced in vitro. Further, colonizing mice with another bacterium exogenously expressing bile-modifying genes from Turicibacter strains decreases serum cholesterol, triglycerides, and adipose tissue mass. This identifies genes that enable Turicibacter strains to modify host bile acids and lipid metabolism, and positions Turicibacter bacteria as modulators of host fat biology.

Date: 2023
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DOI: 10.1038/s41467-023-39403-7

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