Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey

Jingkuan Wei, Shaoxing Dai, Yaping Yan, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang (), Weizhi Ji () and Wei Si ()
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Jingkuan Wei: Kunming University of Science and Technology
Shaoxing Dai: Kunming University of Science and Technology
Yaping Yan: Kunming University of Science and Technology
Shulin Li: Kunming University of Science and Technology
Pengpeng Yang: Kunming University of Science and Technology
Ran Zhu: Kunming University of Science and Technology
Tianzhuang Huang: Kunming University of Science and Technology
Xi Li: Kunming University of Science and Technology
Yanchao Duan: Kunming University of Science and Technology
Zhengbo Wang: Kunming University of Science and Technology
Weizhi Ji: Kunming University of Science and Technology
Wei Si: Kunming University of Science and Technology

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Fetal stages are critical periods for brain development. However, the protein molecular signature and dynamics of the human brain remain unclear due to sampling difficulty and ethical limitations. Non-human primates present similar developmental and neuropathological features to humans. This study constructed a spatiotemporal proteomic atlas of cynomolgus macaque brain development from early fetal to neonatal stages. Here we showed that (1) the variability across stages was greater than that among brain regions, and comparisons of cerebellum vs. cerebrum and cortical vs. subcortical regions revealed region-specific dynamics across early fetal to neonatal stages; (2) fluctuations in abundance of proteins associated with neural disease suggest the risk of nervous disorder at early fetal stages; (3) cross-species analysis (human, monkey, and mouse) and comparison between proteomic and transcriptomic data reveal the proteomic specificity and genes with mRNA/protein discrepancy. This study provides insight into fetal brain development in primates.

Date: 2023
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DOI: 10.1038/s41467-023-39411-7

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