Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles

Jie Cai (), Jie Peng, Juan Feng, Ruocheng Li, Peng Ren, Xinwei Zang, Zezong Wu, Yi Lu, Lin Luo, Zhenzhen Hu, Jiaying Wang, Xiaomeng Dai, Peng Zhao, Juan Wang, Mi Yan, Jianxin Liu, Renren Deng () and Diming Wang ()
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Jie Cai: Zhejiang University
Jie Peng: Zhejiang University
Juan Feng: Zhejiang University
Ruocheng Li: Zhejiang University
Peng Ren: Zhejiang University
Xinwei Zang: Zhejiang University
Zezong Wu: Zhejiang University
Yi Lu: Zhejiang University
Lin Luo: Zhejiang University
Zhenzhen Hu: Zhejiang University
Jiaying Wang: Zhejiang University
Xiaomeng Dai: Zhejiang University
Peng Zhao: Zhejiang University
Juan Wang: Zhejiang University
Mi Yan: Zhejiang University
Jianxin Liu: Zhejiang University
Renren Deng: Zhejiang University
Diming Wang: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Accumulation of inorganic nanoparticles in living organisms can cause an increase in cellular reactive oxygen species (ROS) in a dose-dependent manner. Low doses of nanoparticles have shown possibilities to induce moderate ROS increases and lead to adaptive responses of biological systems, but beneficial effects of such responses on metabolic health remain elusive. Here, we report that repeated oral administrations of various inorganic nanoparticles, including TiO2, Au, and NaYF4 nanoparticles at low doses, can promote lipid degradation and alleviate steatosis in the liver of male mice. We show that low-level uptake of nanoparticles evokes an unusual antioxidant response in hepatocytes by promoting Ces2h expression and consequently enhancing ester hydrolysis. This process can be implemented to treat specific hepatic metabolic disorders, such as fatty liver in both genetic and high-fat-diet obese mice without causing observed adverse effects. Our results demonstrate that low-dose nanoparticle administration may serve as a promising treatment for metabolic regulation.

Date: 2023
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DOI: 10.1038/s41467-023-39423-3

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