A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors

Xin Tong, Jia-Jia Zhao, Ya-Lan Feng, Jing-Ze Zou, Jian Ye, Junfeng Liu, Chenggui Han, Dawei Li and Xian-Bing Wang ()
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Xin Tong: China Agricultural University
Jia-Jia Zhao: China Agricultural University
Ya-Lan Feng: China Agricultural University
Jing-Ze Zou: China Agricultural University
Jian Ye: Institute of Microbiology, Chinese Academy of Sciences
Junfeng Liu: China Agricultural University
Chenggui Han: China Agricultural University
Dawei Li: China Agricultural University
Xian-Bing Wang: China Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation.

Date: 2023
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DOI: 10.1038/s41467-023-39426-0

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