Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice

Sanaya N. Shroff, Eric Lowet (), Sudiksha Sridhar, Howard J. Gritton, Mohammed Abumuaileq, Hua-An Tseng, Cyrus Cheung, Samuel L. Zhou, Krishnakanth Kondabolu and Xue Han ()
Additional contact information
Sanaya N. Shroff: Boston University
Eric Lowet: Boston University
Sudiksha Sridhar: Boston University
Howard J. Gritton: Boston University
Mohammed Abumuaileq: Boston University
Hua-An Tseng: Boston University
Cyrus Cheung: Boston University
Samuel L. Zhou: Boston University
Krishnakanth Kondabolu: Boston University
Xue Han: Boston University

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear how membrane potentials of individual neurons track behavioral rhythms, even though many neurons exhibit pace-making properties in isolated brain circuits. To examine whether single-cell voltage rhythmicity is coupled to behavioral rhythms, we focused on delta-frequencies (1–4 Hz) that are known to occur at both the neural network and behavioral levels. We performed membrane voltage imaging of individual striatal neurons simultaneously with network-level local field potential recordings in mice during voluntary movement. We report sustained delta oscillations in the membrane potentials of many striatal neurons, particularly cholinergic interneurons, which organize spikes and network oscillations at beta-frequencies (20–40 Hz) associated with locomotion. Furthermore, the delta-frequency patterned cellular dynamics are coupled to animals’ stepping cycles. Thus, delta-rhythmic cellular dynamics in cholinergic interneurons, known for their autonomous pace-making capabilities, play an important role in regulating network rhythmicity and movement patterning.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-39497-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39497-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-39497-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().