The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma

Meng Zhou, Siqi Bao, Tongyang Gong, Qiang Wang, Jie Sun, Jiaqi Li, Minyi Lu, Wanyuan Sun, Jianzhong Su (), Hongyan Chen () and Zhihua Liu ()
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Meng Zhou: Wenzhou Medical University
Siqi Bao: Wenzhou Medical University
Tongyang Gong: Chinese Academy of Medical Sciences and Peking Union Medical College
Qiang Wang: Chinese Academy of Medical Sciences and Peking Union Medical College
Jie Sun: Wenzhou Medical University
Jiaqi Li: Wenzhou Medical University
Minyi Lu: Chinese Academy of Medical Sciences and Peking Union Medical College
Wanyuan Sun: Chinese Academy of Medical Sciences and Peking Union Medical College
Jianzhong Su: Wenzhou Medical University
Hongyan Chen: Chinese Academy of Medical Sciences and Peking Union Medical College
Zhihua Liu: Chinese Academy of Medical Sciences and Peking Union Medical College

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC.

Date: 2023
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DOI: 10.1038/s41467-023-39530-1

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