Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study

James F. Mbinta (), Alex X. Wang, Binh P. Nguyen, Janine Paynter, Prosper Mandela A. Awuni, Russell Pine, Andrew A. Sporle, Steve Bowe and Colin R. Simpson ()
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James F. Mbinta: Victoria University of Wellington
Alex X. Wang: Victoria University of Wellington
Binh P. Nguyen: Victoria University of Wellington
Janine Paynter: University of Auckland
Prosper Mandela A. Awuni: Laurentian University
Russell Pine: Victoria University of Wellington
Andrew A. Sporle: Faculty of Science, University of Auckland
Steve Bowe: Victoria University of Wellington
Colin R. Simpson: Victoria University of Wellington

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract In Aotearoa New Zealand, zoster vaccine live is used for the prevention of zoster and associated complications in adults. This study assessed the risk of pre-specified serious adverse events following zoster vaccine live immunisation among adults in routine clinical practice. We conducted a self-controlled case series study using routinely collected national data. We compared the incidence of serious adverse events during the at-risk period with the control period. Rate ratios were estimated using Conditional Poisson regression models. Falsification outcomes analyses were used to evaluate biases in our study population. From April 2018 to July 2021, 278,375 received the vaccine. The rate ratio of serious adverse events following immunisation was 0·43 (95% confidence interval [CI]: 0·37–0·50). There was no significant increase in the risk of cerebrovascular accidents, acute myocardial infarction, acute pericarditis, acute myocarditis, and Ramsay–Hunt Syndrome. The herpes zoster vaccine is safe in adults in Aotearoa New Zealand.

Date: 2023
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DOI: 10.1038/s41467-023-39595-y

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