Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair

Makoto Takeo, Koh-ei Toyoshima, Riho Fujimoto, Tomoyo Iga, Miki Takase, Miho Ogawa and Takashi Tsuji ()
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Makoto Takeo: RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
Koh-ei Toyoshima: RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
Riho Fujimoto: Kwansei-Gakuin University
Tomoyo Iga: RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
Miki Takase: RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
Miho Ogawa: OrganTech Inc.
Takashi Tsuji: RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm.

Date: 2023
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DOI: 10.1038/s41467-023-39605-z

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