Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging

Yinglong Wu, Lihe Sun, Xiaokai Chen, Jiawei Liu, Juan Ouyang, Xiaodong Zhang, Yi Guo, Yun Chen, Wei Yuan, Dongdong Wang, Ting He, Fang Zeng, Hongzhong Chen (), Shuizhu Wu () and Yanli Zhao ()
Additional contact information
Yinglong Wu: Nanyang Technological University
Lihe Sun: South China University of Technology
Xiaokai Chen: Nanyang Technological University
Jiawei Liu: Nanyang Technological University
Juan Ouyang: South China University of Technology
Xiaodong Zhang: Nanyang Technological University
Yi Guo: Nanyang Technological University
Yun Chen: Nanyang Technological University
Wei Yuan: Nanyang Technological University
Dongdong Wang: Nanyang Technological University
Ting He: Nanyang Technological University
Fang Zeng: South China University of Technology
Hongzhong Chen: Nanyang Technological University
Shuizhu Wu: South China University of Technology
Yanli Zhao: Nanyang Technological University

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Organic small-molecule contrast agents have attracted considerable attention in the field of multispectral optoacoustic imaging, but their weak optoacoustic performance resulted from relatively low extinction coefficient and poor water solubility restrains their widespread applications. Herein, we address these limitations by constructing supramolecular assemblies based on cucurbit[8]uril (CB[8]). Two dixanthene-based chromophores (DXP and DXBTZ) are synthesized as the model guest compounds, and then included in CB[8] to prepare host-guest complexes. The obtained DXP-CB[8] and DXBTZ-CB[8] display red-shifted and increased absorption as well as decreased fluorescence, thereby leading to a substantial enhancement in optoacoustic performance. Biological application potential of DXBTZ-CB[8] is investigated after co-assembly with chondroitin sulfate A (CSA). Benefiting from the excellent optoacoustic property of DXBTZ-CB[8] and the CD44-targeting feature of CSA, the formulated DXBTZ-CB[8]/CSA can effectively detect and diagnose subcutaneous tumors, orthotopic bladder tumors, lymphatic metastasis of tumors and ischemia/reperfusion-induced acute kidney injury in mouse models with multispectral optoacoustic imaging.

Date: 2023
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DOI: 10.1038/s41467-023-39610-2

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