Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers

Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant () and Monica Driscoll ()
Additional contact information
Meghan Lee Arnold: Rutgers University
Jason Cooper: Rutgers University
Rebecca Androwski: Rutgers University
Sohil Ardeshna: Rutgers University
Ilija Melentijevic: Rutgers University
Joelle Smart: Rutgers University
Ryan J. Guasp: Rutgers University
Ken C. Q. Nguyen: Rose F. Kennedy Center
Ge Bai: Rutgers University
David H. Hall: Rose F. Kennedy Center
Barth D. Grant: Rutgers University
Monica Driscoll: Rutgers University

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are required cell-autonomously for efficient production of neuronal exophers, giant vesicles that can carry aggregates away from the neuron of origin. The C. elegans aggresome-like organelles we identified are juxtanuclear, HttPolyQ aggregate-enriched, and dependent upon orthologs of mammalian aggresome adaptor proteins, dynein motors, and microtubule integrity for localized aggregate collection. These key hallmarks indicate that conserved mechanisms drive aggresome formation. Furthermore, we found that human neurofilament light chain (NFL) can substitute for C. elegans IFD-2 in promoting exopher extrusion. Taken together, our results suggest a conserved influence of intermediate filament association with aggresomes and neuronal extrusions that eject potentially toxic material. Our findings expand understanding of neuronal proteostasis and suggest implications for neurodegenerative disease progression.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-39700-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39700-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-39700-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().