Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

Nicholas D. Calvert, Alexia Kirby, Mojmír Suchý, Peter Pallister, Aidan A. Torrens, Dylan Burger, Gerd Melkus, Nicola Schieda and Adam J. Shuhendler ()
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Nicholas D. Calvert: University of Ottawa
Alexia Kirby: University of Ottawa
Mojmír Suchý: University of Ottawa
Peter Pallister: Carleton University
Aidan A. Torrens: University of Ottawa
Dylan Burger: University of Ottawa
Gerd Melkus: The Ottawa Hospital
Nicola Schieda: University of Ottawa
Adam J. Shuhendler: University of Ottawa

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney health without spatial information of kidney- or region-specific dysfunction. The addition of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to the anatomical imaging already performed would yield a ‘one-stop-shop’ for renal assessment in cases of suspected AKI and CKD. Towards urography by DCE-MRI, we evaluated a class of nitrogen-centered organic radicals known as verdazyls, which are extremely stable even in highly reducing environments. A glucose-modified verdazyl, glucoverdazyl, provided contrast limited to kidney and bladder, affording functional kidney evaluation in mouse models of unilateral ureteral obstruction (UUO) and folic acid-induced nephropathy (FAN). Imaging outcomes correlated with histology and hematology assessing kidney dysfunction, and glucoverdazyl clearance rates were found to be a reliable surrogate measure of GFR.

Date: 2023
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DOI: 10.1038/s41467-023-39720-x

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