In situ activation of flexible magnetoelectric membrane enhances bone defect repair

Wenwen Liu, Han Zhao, Chenguang Zhang, Shiqi Xu, Fengyi Zhang, Ling Wei, Fangyu Zhu, Ying Chen, Yumin Chen, Ying Huang, Mingming Xu, Ying He, Boon Chin Heng, Jinxing Zhang, Yang Shen, Xuehui Zhang (), Houbing Huang (), Lili Chen () and Xuliang Deng ()
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Wenwen Liu: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Han Zhao: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Chenguang Zhang: Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University
Shiqi Xu: Beijing Institute of Technology
Fengyi Zhang: The Second Xiangya Hospital, Central South University
Ling Wei: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Fangyu Zhu: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Ying Chen: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Yumin Chen: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Ying Huang: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Mingming Xu: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Ying He: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Boon Chin Heng: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Jinxing Zhang: Beijing Normal University
Yang Shen: State Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and Engineering Tsinghua University
Xuehui Zhang: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices
Houbing Huang: Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University
Lili Chen: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xuliang Deng: Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-invasively regulated is highly desirable to avoid further complications and to promote osteogenesis. However, it remains a formidable challenge in clinical applications to achieve efficient osteogenesis with stimuli-responsive materials. Here, we develop polarized CoFe2O4@BaTiO3/poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)] core-shell particle-incorporated composite membranes with high magnetoelectric conversion efficiency for activating bone regeneration. An external magnetic field force conduct on the CoFe2O4 core can increase charge density on the BaTiO3 shell and strengthens the β-phase transition in the P(VDF-TrFE) matrix. This energy conversion increases the membrane surface potential, which hence activates osteogenesis. Skull defect experiments on male rats showed that repeated magnetic field applications on the membranes enhanced bone defect repair, even when osteogenesis repression is elicited by dexamethasone or lipopolysaccharide-induced inflammation. This study provides a strategy of utilizing stimuli-responsive magnetoelectric membranes to efficiently activate osteogenesis in situ.

Date: 2023
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DOI: 10.1038/s41467-023-39744-3

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