Challenges in developing Geroscience trials

Yves Rolland (), Felipe Sierra, Luigi Ferrucci, Nir Barzilai, Rafael Cabo, Joan Mannick, Anthony Oliva, William Evans, Davide Angioni, Philipe Souto Barreto, Jeremy Raffin, Bruno Vellas and James L. Kirkland
Additional contact information
Yves Rolland: Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
Felipe Sierra: Hevolution Foundation
Luigi Ferrucci: National Institutes of Health
Nir Barzilai: Albert Einstein College of Medicine
Rafael Cabo: National Institutes of Health
Joan Mannick: Life Biosciences
Anthony Oliva: Longeveron Inc.
William Evans: University of California
Davide Angioni: Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
Philipe Souto Barreto: Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
Jeremy Raffin: Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
Bruno Vellas: Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
James L. Kirkland: American Federation for Aging Research

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to aging in humans. Researchers will face a number of challenges, including ideal populations to study, which lifestyle and Gerotherapeutic interventions to test initially, selecting key primary and secondary outcomes of such clinical trials, and which age-related biomarkers are most valuable for both selecting interventions and predicting or monitoring clinical responses (“Gerodiagnostics”). This article reports the main results of a Task Force of experts in Geroscience.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-39786-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39786-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-39786-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().