Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Tsion Zewdu Minas, Brittany D. Lord, Amy L. Zhang, Julián Candia, Tiffany H. Dorsey, Francine S. Baker, Wei Tang, Maeve Bailey-Whyte, Cheryl J. Smith, Obadi M. Obadi, Anuoluwapo Ajao, Symone V. Jordan, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Ann W. Hsing, Jia Liu, Christopher A. Loffredo, Clayton Yates, Michael B. Cook and Stefan Ambs ()
Additional contact information
Tsion Zewdu Minas: Center for Cancer Research, National Cancer Institute (NCI)
Brittany D. Lord: Center for Cancer Research, National Cancer Institute (NCI)
Amy L. Zhang: Center for Cancer Research, National Cancer Institute (NCI)
Julián Candia: Center for Cancer Research, National Cancer Institute (NCI)
Tiffany H. Dorsey: Center for Cancer Research, National Cancer Institute (NCI)
Francine S. Baker: Center for Cancer Research, National Cancer Institute (NCI)
Wei Tang: Center for Cancer Research, National Cancer Institute (NCI)
Maeve Bailey-Whyte: Center for Cancer Research, National Cancer Institute (NCI)
Cheryl J. Smith: Center for Cancer Research, National Cancer Institute (NCI)
Obadi M. Obadi: Center for Cancer Research, National Cancer Institute (NCI)
Anuoluwapo Ajao: Center for Cancer Research, National Cancer Institute (NCI)
Symone V. Jordan: Center for Cancer Research, National Cancer Institute (NCI)
Yao Tettey: University of Ghana Medical School
Richard B. Biritwum: University of Ghana Medical School
Andrew A. Adjei: University of Ghana Medical School
James E. Mensah: University of Ghana Medical School
Robert N. Hoover: Division of Cancer Epidemiology & Genetics, NCI
Ann W. Hsing: Stanford University
Jia Liu: Cancer Genomics Research Laboratory, NCI
Christopher A. Loffredo: Georgetown University
Clayton Yates: Johns Hopkins University School of Medicine
Michael B. Cook: Division of Cancer Epidemiology & Genetics, NCI
Stefan Ambs: Center for Cancer Research, National Cancer Institute (NCI)

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, suggesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders.

Date: 2023
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DOI: 10.1038/s41467-023-39865-9

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