Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans

Fan Xu, Ruoyao Li, Erika D. Gromoff, Friedel Drepper, Bettina Knapp, Bettina Warscheid, Ralf Baumeister and Wenjing Qi ()
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Fan Xu: Albert-Ludwigs-University Freiburg
Ruoyao Li: Albert-Ludwigs-University Freiburg
Erika D. Gromoff: Albert-Ludwigs-University Freiburg
Friedel Drepper: Albert-Ludwigs-University Freiburg
Bettina Knapp: Albert-Ludwigs-University Freiburg
Bettina Warscheid: Albert-Ludwigs-University Freiburg
Ralf Baumeister: Albert-Ludwigs-University Freiburg
Wenjing Qi: Albert-Ludwigs-University Freiburg

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Transient stress experiences not only trigger acute stress responses, but can also have long-lasting effects on cellular functions. In Caenorhabditis elegans, a brief exposure to heat shock during early adulthood extends lifespan and improves stress resistance, a phenomenon known as heat hormesis. Here, we investigated the prolonged effect of hormetic heat stress on the transcriptome of worms and found that the canonical heat shock response is followed by a profound transcriptional reprogramming in the post-stress period. This reprogramming relies on the endoribonuclease ENDU-2 but not the heat shock factor 1. ENDU-2 co-localizes with chromatin and interacts with RNA polymerase II, enabling specific regulation of transcription after the stress period. Failure to activate the post-stress response does not affect the resistance of animals to heat shock but eliminates the beneficial effects of hormetic heat stress. In summary, our work discovers that the RNA-binding protein ENDU-2 mediates the long-term impacts of transient heat stress via reprogramming transcriptome after stress exposure.

Date: 2023
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DOI: 10.1038/s41467-023-39882-8

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