Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion

Rory Osborne, Laura Rehneke, Silke Lehmann, Jemma Roberts, Melina Altmann, Stefan Altmann, Yingqi Zhang, Eva Köpff, Ana Dominguez-Ferreras, Emeka Okechukwu, Chrysi Sergaki, Charlotte Rich-Griffin, Vardis Ntoukakis, Ruth Eichmann, Weixing Shan, Pascal Falter-Braun () and Patrick Schäfer ()
Additional contact information
Rory Osborne: University of Warwick
Laura Rehneke: Justus Liebig University
Silke Lehmann: University of Warwick
Jemma Roberts: University of Warwick
Melina Altmann: Helmholtz Munich
Stefan Altmann: Helmholtz Munich
Yingqi Zhang: Northwest A&F University
Eva Köpff: Ulm University
Ana Dominguez-Ferreras: University of Warwick
Emeka Okechukwu: University of Warwick
Chrysi Sergaki: University of Warwick
Charlotte Rich-Griffin: University of Warwick
Vardis Ntoukakis: University of Warwick
Ruth Eichmann: Justus Liebig University
Weixing Shan: Northwest A&F University
Pascal Falter-Braun: Helmholtz Munich
Patrick Schäfer: Justus Liebig University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Plants have benefited from interactions with symbionts for coping with challenging environments since the colonisation of land. The mechanisms of symbiont-mediated beneficial effects and similarities and differences to pathogen strategies are mostly unknown. Here, we use 106 (effector-) proteins, secreted by the symbiont Serendipita indica (Si) to modulate host physiology, to map interactions with Arabidopsis thaliana host proteins. Using integrative network analysis, we show significant convergence on target-proteins shared with pathogens and exclusive targeting of Arabidopsis proteins in the phytohormone signalling network. Functional in planta screening and phenotyping of Si effectors and interacting proteins reveals previously unknown hormone functions of Arabidopsis proteins and direct beneficial activities mediated by effectors in Arabidopsis. Thus, symbionts and pathogens target a shared molecular microbe-host interface. At the same time Si effectors specifically target the plant hormone network and constitute a powerful resource for elucidating the signalling network function and boosting plant productivity.

Date: 2023
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DOI: 10.1038/s41467-023-39885-5

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