SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates

Elisabeth A. Murphy, Camila Guzman-Cardozo, Ashley C. Sukhu, Debby J. Parks, Malavika Prabhu, Iman Mohammed, Magdalena Jurkiewicz, Thomas J. Ketas, Sunidhi Singh, Marie Canis, Eva Bednarski, Alexis Hollingsworth, Embree M. Thompson, Dorothy Eng, Paul D. Bieniasz, Laura E. Riley, Theodora Hatziioannou () and Yawei J. Yang ()
Additional contact information
Elisabeth A. Murphy: Weill Cornell Medicine
Camila Guzman-Cardozo: The Rockefeller University
Ashley C. Sukhu: New York Presbyterian/Weill Cornell Medical Center
Debby J. Parks: The Rockefeller University
Malavika Prabhu: Weill Cornell Medicine
Iman Mohammed: Weill Cornell Medicine
Magdalena Jurkiewicz: Weill Cornell Medicine
Thomas J. Ketas: Weill Cornell Medicine
Sunidhi Singh: Weill Cornell Medicine
Marie Canis: The Rockefeller University
Eva Bednarski: The Rockefeller University
Alexis Hollingsworth: Weill Cornell Medicine
Embree M. Thompson: Weill Cornell Medicine
Dorothy Eng: New York Presbyterian/Weill Cornell Medical Center
Paul D. Bieniasz: The Rockefeller University
Laura E. Riley: Weill Cornell Medicine
Theodora Hatziioannou: The Rockefeller University
Yawei J. Yang: Weill Cornell Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity. We further study the ability of maternal antibody and neutralizing measurements to predict neutralizing antibody activity in the umbilical cord blood of neonates. In this work, we show SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity even against the recent omicron BA.1 and BA.5 variants in both pregnant patients and their neonates.

Date: 2023
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DOI: 10.1038/s41467-023-39989-y

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