Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Ana Babic, Michael H. Rosenthal, Tilak K. Sundaresan, Natalia Khalaf, Valerie Lee, Lauren K. Brais, Maureen Loftus, Leah Caplan, Sarah Denning, Anamol Gurung, Joanna Harrod, Khoschy Schawkat, Chen Yuan, Qiao-Li Wang, Alice A. Lee, Leah H. Biller, Matthew B. Yurgelun, Kimmie Ng, Jonathan A. Nowak, Andrew J. Aguirre, Sangeeta N. Bhatia, Matthew G. Heiden, Stephen K. Eeden, Bette J. Caan and Brian M. Wolpin ()
Additional contact information
Ana Babic: Dana-Farber Cancer Institute
Michael H. Rosenthal: Brigham and Women’s Hospital and Harvard Medical School
Tilak K. Sundaresan: Kaiser Permanente San Francisco
Natalia Khalaf: Baylor College of Medicine
Valerie Lee: Kaiser Permanente Northern California
Lauren K. Brais: Dana-Farber Cancer Institute
Maureen Loftus: Dana-Farber Cancer Institute
Leah Caplan: Dana-Farber Cancer Institute
Sarah Denning: Dana-Farber Cancer Institute
Anamol Gurung: Dana-Farber Cancer Institute
Joanna Harrod: Dana-Farber Cancer Institute
Khoschy Schawkat: Brigham and Women’s Hospital and Harvard Medical School
Chen Yuan: Dana-Farber Cancer Institute
Qiao-Li Wang: Dana-Farber Cancer Institute
Alice A. Lee: Brigham and Women’s Hospital and Harvard Medical School
Leah H. Biller: Dana-Farber Cancer Institute
Matthew B. Yurgelun: Dana-Farber Cancer Institute
Kimmie Ng: Dana-Farber Cancer Institute
Jonathan A. Nowak: Brigham and Women’s Hospital and Harvard Medical School
Andrew J. Aguirre: Dana-Farber Cancer Institute
Sangeeta N. Bhatia: Brigham and Women’s Hospital and Harvard Medical School
Matthew G. Heiden: Dana-Farber Cancer Institute
Stephen K. Eeden: Kaiser Permanente Northern California
Bette J. Caan: Kaiser Permanente Northern California
Brian M. Wolpin: Dana-Farber Cancer Institute

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared with metastatic disease and are not correlated with at-diagnosis circulating levels of CA19-9. Skeletal muscle wasting occurs in the 1–2 years before pancreatic cancer diagnosis and may signal an upcoming diagnosis of pancreatic cancer.

Date: 2023
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DOI: 10.1038/s41467-023-40024-3

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