Nucleus reuniens transiently synchronizes memory networks at beta frequencies

Maanasa Jayachandran, Tatiana D. Viena, Andy Garcia, Abdiel Vasallo Veliz, Sofia Leyva, Valentina Roldan, Robert P. Vertes and Timothy A. Allen ()
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Maanasa Jayachandran: Florida International University
Tatiana D. Viena: Florida International University
Andy Garcia: Florida International University
Abdiel Vasallo Veliz: Florida International University
Sofia Leyva: Florida International University
Valentina Roldan: Florida International University
Robert P. Vertes: Florida Atlantic University
Timothy A. Allen: Florida International University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Episodic memory-based decision-making requires top-down medial prefrontal cortex and hippocampal interactions. This integrated prefrontal-hippocampal memory state is thought to be organized by synchronized network oscillations and mediated by connectivity with the thalamic nucleus reuniens (RE). Whether and how the RE synchronizes prefrontal-hippocampal networks in memory, however, remains unknown. Here, we recorded local field potentials from the prefrontal-RE-hippocampal network while rats engaged in a nonspatial sequence memory task, thereby isolating memory-related activity from running-related oscillations. We found that synchronous prefrontal-hippocampal beta bursts (15–30 Hz) dominated during memory trials, whereas synchronous theta activity (6–12 Hz) dominated during non-memory–related running. Moreover, RE beta activity appeared first, followed by prefrontal and hippocampal synchronized beta, suggesting that prefrontal-hippocampal beta could be driven by the RE. To test whether the RE is capable of driving prefrontal-hippocampal beta synchrony, we used an optogenetic approach (retroAAV-ChR2). RE activation induced prefrontal-hippocampal beta coherence and reduced theta coherence, matching the observed memory-driven network state in the sequence task. These findings are the first to demonstrate that the RE contributes to memory by driving transient synchronized beta in the prefrontal-hippocampal system, thereby facilitating interactions that underlie memory-based decision-making.

Date: 2023
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DOI: 10.1038/s41467-023-40044-z

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