Association between vmPFC gray matter volume and smoking initiation in adolescents

Shitong Xiang, Tianye Jia (), Chao Xie, Wei Cheng, Bader Chaarani, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny A. Gowland, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Hugh Garavan, Gunter Schumann, Barbara J. Sahakian, Trevor W. Robbins () and Jianfeng Feng ()
Additional contact information
Shitong Xiang: Fudan University
Tianye Jia: Fudan University
Chao Xie: Fudan University
Wei Cheng: Fudan University
Bader Chaarani: University of Vermont
Tobias Banaschewski: Medical Faculty Mannheim, Heidelberg University
Gareth J. Barker: King’s College London
Arun L. W. Bokde: Trinity College Dublin
Christian Büchel: University Medical Centre Hamburg-Eppendorf
Sylvane Desrivières: King’s College London
Herta Flor: Heidelberg University
Antoine Grigis: Université Paris-Saclay
Penny A. Gowland: University of Nottingham
Rüdiger Brühl: Physikalisch-Technische Bundesanstalt (PTB)
Jean-Luc Martinot: Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
Marie-Laure Paillère Martinot: Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
Frauke Nees: Medical Faculty Mannheim, Heidelberg University
Dimitri Papadopoulos Orfanos: School of Social Sciences, University of Mannheim
Luise Poustka: Center for Psychosocial Medicine, University Hospital Heidelberg
Sarah Hohmann: Medical Faculty Mannheim, Heidelberg University
Juliane H. Fröhner: Technische Universität Dresden
Michael N. Smolka: Technische Universität Dresden
Nilakshi Vaidya: Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
Henrik Walter: Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
Robert Whelan: Trinity College Dublin
Hugh Garavan: University of Vermont
Gunter Schumann: Fudan University
Barbara J. Sahakian: Fudan University
Trevor W. Robbins: Fudan University
Jianfeng Feng: Fudan University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

Date: 2023
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DOI: 10.1038/s41467-023-40079-2

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