Purkinje cell microzones mediate distinct kinematics of a single movement

François G. C. Blot, Joshua J. White, Amy van Hattem, Licia Scotti, Vaishnavi Balaji, Youri Adolfs, R. Jeroen Pasterkamp, Chris I. De Zeeuw and Martijn Schonewille ()
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François G. C. Blot: Erasmus MC
Joshua J. White: Erasmus MC
Amy van Hattem: Erasmus MC
Licia Scotti: Erasmus MC
Vaishnavi Balaji: Erasmus MC
Youri Adolfs: University Medical Center Utrecht, Brain Center, Utrecht University
R. Jeroen Pasterkamp: University Medical Center Utrecht, Brain Center, Utrecht University
Chris I. De Zeeuw: Erasmus MC
Martijn Schonewille: Erasmus MC

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract The classification of neuronal subpopulations has significantly advanced, yet its relevance for behavior remains unclear. The highly organized flocculus of the cerebellum, known to fine-tune multi-axial eye movements, is an ideal substrate for the study of potential functions of neuronal subpopulations. Here, we demonstrate that its recently identified subpopulations of 9+ and 9- Purkinje cells exhibit an intermediate Aldolase C expression and electrophysiological profile, providing evidence for a graded continuum of intrinsic properties among PC subpopulations. By identifying and utilizing two Cre-lines that genetically target these floccular domains, we show with high spatial specificity that these subpopulations of Purkinje cells participate in separate micromodules with topographically organized connections. Finally, optogenetic excitation of the respective subpopulations results in movements around the same axis in space, yet with distinct kinematic profiles. These results indicate that Purkinje cell subpopulations integrate in discrete circuits and mediate particular parameters of single movements.

Date: 2023
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DOI: 10.1038/s41467-023-40111-5

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