In situ assembly of bioresorbable organic bioelectronics in the brain

Martin Hjort, Abdelrazek H. Mousa, David Bliman, Muhammad Anwar Shameem, Karin Hellman, Amit Singh Yadav, Peter Ekström, Fredrik Ek and Roger Olsson ()
Additional contact information
Martin Hjort: Lund University
Abdelrazek H. Mousa: University of Gothenburg
David Bliman: University of Gothenburg
Muhammad Anwar Shameem: University of Gothenburg
Karin Hellman: Lund University
Amit Singh Yadav: Lund University
Peter Ekström: Lund University
Fredrik Ek: Lund University
Roger Olsson: Lund University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria and integrate seamlessly into dynamic biological systems in ways difficult for classical rigid solid-state electronics. Here we place bioresorbable electrodes with a brain-matched shear modulus—made from water-dispersed nanoparticles in the brain—in the targeted area using a capillary thinner than a human hair. Thereafter, we show that an optional auxiliary module grows dendrites from the installed conductive structure to seamlessly embed neurons and modify the electrode’s volume properties. We demonstrate that these soft electrodes set off a controlled cellular response in the brain when relaying external stimuli and that the biocompatible materials show no tissue damage after bioresorption. These findings encourage further investigation of temporary organic bioelectronics for nonchronic treatments assembled in vivo.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-40175-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40175-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-40175-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().