A flexible optoacoustic blood ‘stethoscope’ for noninvasive multiparametric cardiovascular monitoring

Haoran Jin, Zesheng Zheng, Zequn Cui, Ying Jiang, Geng Chen, Wenlong Li, Zhimin Wang, Jilei Wang, Chuanshi Yang, Weitao Song, Xiaodong Chen () and Yuanjin Zheng ()
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Haoran Jin: Nanyang Technological University
Zesheng Zheng: Nanyang Technological University
Zequn Cui: Nanyang Technological University
Ying Jiang: Nanyang Technological University
Geng Chen: Nanyang Technological University
Wenlong Li: Nanyang Technological University
Zhimin Wang: Nanyang Technological University
Jilei Wang: Nanyang Technological University
Chuanshi Yang: Nanyang Technological University
Weitao Song: Nanyang Technological University
Xiaodong Chen: Nanyang Technological University
Yuanjin Zheng: Nanyang Technological University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Quantitative and multiparametric blood analysis is of great clinical importance in cardiovascular disease diagnosis. Although there are various methods to extract blood information, they often require invasive procedures, lack continuity, involve bulky instruments, or have complicated testing procedures. Flexible sensors can realize on-skin assessment of several vital signals, but generally exhibit limited function to monitor blood characteristics. Here, we report a flexible optoacoustic blood ‘stethoscope’ for noninvasive, multiparametric, and continuous cardiovascular monitoring, without requiring complicated procedures. The optoacoustic blood ‘stethoscope’ features the light delivery elements to illuminate blood and the piezoelectric acoustic elements to capture light-induced acoustic waves. We show that the optoacoustic blood ‘stethoscope’ can adhere to the skin for continuous and non-invasive in-situ monitoring of multiple cardiovascular biomarkers, including hypoxia, intravascular exogenous agent concentration decay, and hemodynamics, which can be further visualized with a tailored 3D algorithm. Demonstrations on both in-vivo animal trials and human subjects highlight the optoacoustic blood ‘stethoscope’‘s potential for cardiovascular disease diagnosis and prediction.

Date: 2023
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DOI: 10.1038/s41467-023-40181-5

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