Tapping the rhizosphere metabolites for the prebiotic control of soil-borne bacterial wilt disease

Tao Wen, Penghao Xie, Hongwei Liu, Ting Liu, Mengli Zhao, Shengdie Yang, Guoqing Niu, Lauren Hale, Brajesh K. Singh, George A. Kowalchuk, Qirong Shen and Jun Yuan ()
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Tao Wen: Nanjing Agricultural University
Penghao Xie: Nanjing Agricultural University
Hongwei Liu: Western Sydney University
Ting Liu: Nanjing Agricultural University
Mengli Zhao: Nanjing Agricultural University
Shengdie Yang: Nanjing Agricultural University
Guoqing Niu: Nanjing Agricultural University
Lauren Hale: San Joaquin Valley Agricultural Sciences Center
Brajesh K. Singh: Western Sydney University
George A. Kowalchuk: Institute of Environmental Biology, Utrecht University
Qirong Shen: Nanjing Agricultural University
Jun Yuan: Nanjing Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Prebiotics are compounds that selectively stimulate the growth and activity of beneficial microorganisms. The use of prebiotics is a well-established strategy for managing human gut health. This concept can also be extended to plants where plant rhizosphere microbiomes can improve the nutrient acquisition and disease resistance. However, we lack effective strategies for choosing metabolites to elicit the desired impacts on plant health. In this study, we target the rhizosphere of tomato (Solanum lycopersicum) suffering from wilt disease (caused by Ralstonia solanacearum) as source for potential prebiotic metabolites. We identify metabolites (ribose, lactic acid, xylose, mannose, maltose, gluconolactone, and ribitol) exclusively used by soil commensal bacteria (not positively correlated with R. solanacearum) but not efficiently used by the pathogen in vitro. Metabolites application in the soil with 1 µmol g−1 soil effectively protects tomato and other Solanaceae crops, pepper (Capsicum annuum) and eggplant (Solanum melongena), from pathogen invasion. After adding prebiotics, the rhizosphere soil microbiome exhibits enrichment of pathways related to carbon metabolism and autotoxin degradation, which were driven by commensal microbes. Collectively, we propose a novel pathway for mining metabolites from the rhizosphere soil and their use as prebiotics to help control soil-borne bacterial wilt diseases.

Date: 2023
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DOI: 10.1038/s41467-023-40184-2

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