Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer

Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li () and Zigang Dong ()
Additional contact information
Xuejiao Liu: Zhengzhou University
Simin Zhao: China-US (Henan) Hormel Cancer Institute
Keke Wang: China-US (Henan) Hormel Cancer Institute
Liting Zhou: Zhengzhou University
Ming Jiang: China-US (Henan) Hormel Cancer Institute
Yunfeng Gao: China-US (Henan) Hormel Cancer Institute
Ran Yang: China-US (Henan) Hormel Cancer Institute
Shiwen Yan: Zhengzhou University
Wen Zhang: Zhengzhou University
Bingbing Lu: Zhengzhou University
Feifei Liu: Zhengzhou University
Ran Zhao: Zhengzhou University
Wenting Liu: Zhengzhou University
Zihan Zhang: Zhengzhou University
Kangdong Liu: Zhengzhou University
Xiang Li: Zhengzhou University
Zigang Dong: Zhengzhou University

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal squamous cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. Due to the absence of molecular indicators, which ESPL will eventually develop into ESCC and thus should be treated is not well defined. Indicators, for predicting risks of ESCC at ESPL stages, are an urgent need. We perform spatial whole-transcriptome atlas analysis, which can eliminate other tissue interference by sequencing the specific ESPL regions. In this study, the expression of TAGLN2 significantly increases, while CRNN expression level decreases along the progression of ESCC. Additionally, TAGLN2 protein level significantly increases in paired after-progression tissues compared with before-progression samples, while CRNN expression decreases. Functional studies suggest that TAGLN2 promotes ESCC progression, while CRNN inhibits it by regulating cell proliferation. Taken together, TAGLN2 and CRNN are suggested as candidate indicators for the risk of ESCC at ESPL stages.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-40343-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40343-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-40343-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().