BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling

Jiaojiao Bai, Yuanyuan Zhou, Jianhang Sun, Kexin Chen, Yufang Han, Ranran Wang, Yanmin Zou, Mingshuo Du and Dongping Lu ()
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Jiaojiao Bai: Chinese Academy of Sciences
Yuanyuan Zhou: Chinese Academy of Sciences
Jianhang Sun: Chinese Academy of Sciences
Kexin Chen: Chinese Academy of Sciences
Yufang Han: Chinese Academy of Sciences
Ranran Wang: Chinese Academy of Sciences
Yanmin Zou: Chinese Academy of Sciences
Mingshuo Du: Chinese Academy of Sciences
Dongping Lu: Shanghai Jiao Tong University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Pathogen-associated molecular patterns (PAMPs) trigger plant innate immunity that acts as the first line of inducible defense against pathogen infection. A receptor-like cytoplasmic kinase BOTRYTIS-INDUCED KINASE 1 (BIK1) functions as a signaling hub immediately downstream of multiple pattern recognition receptors (PRRs). It is known that PLANT U-BOX PROTEIN 25 (PUB25) and PUB26 ubiquitinate BIK1 and mediate BIK1 degradation. However, how BIK1 homeostasis is maintained is not fully understood. Here, we show that two closely related ubiquitin ligases, RING DOMAIN LIGASE 1 (RGLG1) and RGLG2, preferentially associate with the hypo-phosphorylated BIK1 and promote the association of BIK1 with the co-receptor for several PRRs, BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1). PUB25 interacts with RGLG2 and mediates its degradation. In turn, RGLG2 represses the ubiquitin ligase activity of PUB25. RGLG1/2 suppress PUB25-mediated BIK1 degradation, promote BIK1 protein accumulation, and positively regulate immune signaling in a ubiquitin ligase activity-dependent manner. Our work reveals how BIK1 homeostasis is maintained by the interplay of different ubiquitin ligases.

Date: 2023
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DOI: 10.1038/s41467-023-40364-0

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