ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana

Agata Zubrycka, Charlene Dambire, Laura Dalle Carbonare, Gunjan Sharma, Tinne Boeckx, Kamal Swarup, Craig J. Sturrock, Brian S. Atkinson, Ranjan Swarup, Françoise Corbineau, Neil J. Oldham and Michael J. Holdsworth ()
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Agata Zubrycka: University of Nottingham
Charlene Dambire: University of Nottingham
Laura Dalle Carbonare: University of Nottingham
Gunjan Sharma: University of Nottingham
Tinne Boeckx: University of Nottingham
Kamal Swarup: University of Nottingham
Craig J. Sturrock: University of Nottingham
Brian S. Atkinson: University of Nottingham
Ranjan Swarup: University of Nottingham
Françoise Corbineau: Sorbonne Université
Neil J. Oldham: University of Nottingham, University Park
Michael J. Holdsworth: University of Nottingham

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Oxygen is a key signalling component of plant biology, and whilst an oxygen-sensing mechanism was previously described in Arabidopsis thaliana, key features of the associated PLANT CYSTEINE OXIDASE (PCO) N-degron pathway and Group VII ETHYLENE RESPONSE FACTOR (ERFVII) transcription factor substrates remain untested or unknown. We demonstrate that ERFVIIs show non-autonomous activation of root hypoxia tolerance and are essential for root development and survival under oxygen limiting conditions in soil. We determine the combined effects of ERFVIIs in controlling gene expression and define genetic and environmental components required for proteasome-dependent oxygen-regulated stability of ERFVIIs through the PCO N-degron pathway. Using a plant extract, unexpected amino-terminal cysteine sulphonic acid oxidation level of ERFVIIs was observed, suggesting a requirement for additional enzymatic activity within the pathway. Our results provide a holistic understanding of the properties, functions and readouts of this oxygen-sensing mechanism defined through its role in modulating ERFVII stability.

Date: 2023
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DOI: 10.1038/s41467-023-40366-y

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