Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses

Huixin Li, Yanpeng Xu, Yang Wang, Yihao Cui, Jiake Lin, Yuemin Zhou, Shuling Tang, Ying Zhang, Haibin Hao, Zihao Nie, Xiaoyu Wang () and Ruikang Tang ()
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Huixin Li: Zhejiang University
Yanpeng Xu: Capital Institute of Pediatrics
Yang Wang: Nantong University
Yihao Cui: Zhejiang University
Jiake Lin: Zhejiang University
Yuemin Zhou: Zhejiang University
Shuling Tang: Zhejiang University
Ying Zhang: Zhejiang University
Haibin Hao: Zhejiang University
Zihao Nie: Zhejiang University
Xiaoyu Wang: Zhejiang University
Ruikang Tang: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Material-based tactics have attracted extensive attention in driving the functional evolution of organisms. In aiming to design steerable bioartificial organisms to scavenge pathogenic waterborne viruses, we engineer Paramecium caudatum (Para), single-celled microorganisms, with a semiartificial and specific virus-scavenging organelle (VSO). Fe3O4 magnetic nanoparticles modified with a virus-capture antibody (MNPs@Ab) are integrated into the vacuoles of Para during feeding to produce VSOs, which persist inside Para without impairing their swimming ability. Compared with natural Para, which has no capture specificity and shows inefficient inactivation, the VSO-engineered Para (E-Para) specifically gathers waterborne viruses and confines them inside the VSOs, where the captured viruses are completely deactivated because the peroxidase-like nano-Fe3O4 produces virus-killing hydroxyl radicals (•OH) within acidic environment of VSO. After treatment, magnetized E-Para is readily recycled and reused, avoiding further contamination. Materials-based artificial organelles convert natural Para into a living virus scavenger, facilitating waterborne virus clearance without extra energy consumption.

Date: 2023
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DOI: 10.1038/s41467-023-40397-5

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