A translational regulator MHZ9 modulates ethylene signaling in rice

Yi-Hua Huang, Jia-Qi Han, Biao Ma, Wu-Qiang Cao, Xin-Kai Li, Qing Xiong, He Zhao, Rui Zhao, Xun Zhang, Yang Zhou, Wei Wei, Jian-Jun Tao, Wan-Ke Zhang, Wenfeng Qian, Shou-Yi Chen, Chao Yang (), Cui-Cui Yin () and Jin-Song Zhang ()
Additional contact information
Yi-Hua Huang: Chinese Academy of Sciences
Jia-Qi Han: Chinese Academy of Sciences
Biao Ma: College of Agriculture, South China Agricultural University
Wu-Qiang Cao: Chinese Academy of Sciences
Xin-Kai Li: Chinese Academy of Sciences
Qing Xiong: Sichuan Agricultural University
He Zhao: Chinese Academy of Sciences
Rui Zhao: Chinese Academy of Sciences
Xun Zhang: Chinese Academy of Sciences
Yang Zhou: Chinese Academy of Sciences
Wei Wei: Chinese Academy of Sciences
Jian-Jun Tao: Chinese Academy of Sciences
Wan-Ke Zhang: Chinese Academy of Sciences
Wenfeng Qian: Chinese Academy of Sciences
Shou-Yi Chen: Chinese Academy of Sciences
Chao Yang: China Agricultural University
Cui-Cui Yin: Chinese Academy of Sciences
Jin-Song Zhang: Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Ethylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in rice. Here, through analysis of an ethylene-response mutant mhz9, we identified a glycine-tyrosine-phenylalanine (GYF) domain protein MHZ9, which positively regulates ethylene signaling at translational level in rice. MHZ9 is localized in RNA processing bodies. The C-terminal domain of MHZ9 interacts with OsEIN2, a central regulator of rice ethylene signaling, and the N-terminal domain directly binds to the OsEBF1/2 mRNAs for translational inhibition, allowing accumulation of transcription factor OsEIL1 to activate the downstream signaling. RNA-IP seq and CLIP-seq analyses reveal that MHZ9 associates with hundreds of RNAs. Ribo-seq analysis indicates that MHZ9 is required for the regulation of ~ 90% of genes translationally affected by ethylene. Our study identifies a translational regulator MHZ9, which mediates translational regulation of genes in response to ethylene, facilitating stress adaptation and trait improvement in rice.

Date: 2023
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DOI: 10.1038/s41467-023-40429-0

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