Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Liu-Chun Wang, Pei-Yu Chiou, Ya-Ping Hsu, Chin-Lai Lee, Chih-Hsuan Hung, Yi-Hsuan Wu, Wen-Jyun Wang, Gia-Ling Hsieh, Ying-Chi Chen, Li-Chan Chang, Wen-Pin Su, Divinah Manoharan, Min-Chiao Liao, Suresh Thangudu, Wei-Peng Li (), Chia-Hao Su (), Hong-Kang Tian () and Chen-Sheng Yeh ()
Additional contact information
Liu-Chun Wang: National Cheng Kung University
Pei-Yu Chiou: National Cheng Kung University
Ya-Ping Hsu: National Cheng Kung University
Chin-Lai Lee: Kaohsiung Chang Gung Memorial Hospital
Chih-Hsuan Hung: National Cheng Kung University
Yi-Hsuan Wu: National Cheng Kung University
Wen-Jyun Wang: Kaohsiung Medical University
Gia-Ling Hsieh: National Cheng Kung University
Ying-Chi Chen: National Cheng Kung University
Li-Chan Chang: National Cheng Kung University
Wen-Pin Su: National Cheng Kung University
Divinah Manoharan: National Cheng Kung University
Min-Chiao Liao: Kaohsiung Chang Gung Memorial Hospital
Suresh Thangudu: Chang Gung University
Wei-Peng Li: Kaohsiung Medical University
Chia-Hao Su: Chang Gung University
Hong-Kang Tian: National Cheng Kung University
Chen-Sheng Yeh: National Cheng Kung University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+-N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O2, H2O2, and ‧OH from H2O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

Date: 2023
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DOI: 10.1038/s41467-023-40470-z

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