Autophagy promotes jasmonate-mediated defense against nematodes

Jinping Zou, Xinlin Chen, Chenxu Liu, Mingyue Guo, Mukesh Kumar Kanwar, Zhenyu Qi, Ping Yang, Guanghui Wang, Yan Bao, Diane C. Bassham, Jingquan Yu and Jie Zhou ()
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Jinping Zou: Zhejiang University
Xinlin Chen: Zhejiang University
Chenxu Liu: Zhejiang University
Mingyue Guo: Zhejiang University
Mukesh Kumar Kanwar: Zhejiang University
Zhenyu Qi: Zhejiang University
Ping Yang: Zhejiang University
Guanghui Wang: Zhejiang University
Yan Bao: Shanghai Jiao Tong University
Diane C. Bassham: Iowa State University
Jingquan Yu: Zhejiang University
Jie Zhou: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Autophagy, as an intracellular degradation system, plays a critical role in plant immunity. However, the involvement of autophagy in the plant immune system and its function in plant nematode resistance are largely unknown. Here, we show that root-knot nematode (RKN; Meloidogyne incognita) infection induces autophagy in tomato (Solanum lycopersicum) and different atg mutants exhibit high sensitivity to RKNs. The jasmonate (JA) signaling negative regulators JASMONATE-ASSOCIATED MYC2-LIKE 1 (JAM1), JAM2 and JAM3 interact with ATG8s via an ATG8-interacting motif (AIM), and JAM1 is degraded by autophagy during RKN infection. JAM1 impairs the formation of a transcriptional activation complex between ETHYLENE RESPONSE FACTOR 1 (ERF1) and MEDIATOR 25 (MED25) and interferes with transcriptional regulation of JA-mediated defense-related genes by ERF1. Furthermore, ERF1 acts in a positive feedback loop and regulates autophagy activity by transcriptionally activating ATG expression in response to RKN infection. Therefore, autophagy promotes JA-mediated defense against RKNs via forming a positive feedback circuit in the degradation of JAMs and transcriptional activation by ERF1.

Date: 2023
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DOI: 10.1038/s41467-023-40472-x

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