Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish

Juan P. García-López, Alexandre Grimaldi, Zelin Chen, Claudio Meneses, Karina Bravo-Tello, Erica Bresciani, Alvaro Banderas, Shawn M. Burgess (), Pedro P. Hernández () and Carmen G. Feijoo ()
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Juan P. García-López: Andres Bello University
Alexandre Grimaldi: Institut Pasteur
Zelin Chen: Chinese Academy of Sciences
Claudio Meneses: Millennium Nucleus Development of Super Adaptable Plants (MN-SAP)
Karina Bravo-Tello: Andres Bello University
Erica Bresciani: National Human Genome Research Institute
Alvaro Banderas: CNRS UMR168, Laboratoire Physico Chimie Curie
Shawn M. Burgess: National Human Genome Research Institute
Pedro P. Hernández: PSL Research University, INSERM U934/CNRS UMR3215, Development and Homeostasis of Mucosal Tissues Lab
Carmen G. Feijoo: Andres Bello University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract The current view of hematopoiesis considers leukocytes on a continuum with distinct developmental origins, and which exert non-overlapping functions. However, there is less known about the function and phenotype of ontogenetically distinct neutrophil populations. In this work, using a photoconvertible transgenic zebrafish line; Tg(mpx:Dendra2), we selectively label rostral blood island-derived and caudal hematopoietic tissue-derived neutrophils in vivo during steady state or upon injury. By comparing the migratory properties and single-cell expression profiles of both neutrophil populations at steady state we show that rostral neutrophils show higher csf3b expression and migration capacity than caudal neutrophils. Upon injury, both populations share a core transcriptional profile as well as subset-specific transcriptional signatures. Accordingly, both rostral and caudal neutrophils are recruited to the wound independently of their distance to the injury. While rostral neutrophils respond uniformly, caudal neutrophils respond heterogeneously. Collectively, our results reveal that co-existing neutrophils populations with ontogenically distinct origin display functional differences.

Date: 2023
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DOI: 10.1038/s41467-023-40662-7

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