Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation

Moises Freitas-Andrade, Cesar H. Comin, Peter Dyken, Julie Ouellette, Joanna Raman-Nair, Nicole Blakeley, Qing Yan Liu, Sonia Leclerc, Youlian Pan, Ziying Liu, Micaël Carrier, Karan Thakur, Alexandre Savard, Gareth M. Rurak, Marie-Ève Tremblay, Natalina Salmaso, Luciano da F. Costa, Gianfilippo Coppola and Baptiste Lacoste ()
Additional contact information
Moises Freitas-Andrade: The Ottawa Hospital Research Institute
Cesar H. Comin: Federal University of São Carlos, Department of Computer Science
Peter Dyken: University of Ottawa
Julie Ouellette: The Ottawa Hospital Research Institute
Joanna Raman-Nair: The Ottawa Hospital Research Institute
Nicole Blakeley: The Ottawa Hospital Research Institute
Qing Yan Liu: National Research Council of Canada, Human Health and Therapeutics
Sonia Leclerc: National Research Council of Canada, Human Health and Therapeutics
Youlian Pan: National Research Council of Canada
Ziying Liu: National Research Council of Canada
Micaël Carrier: University of Victoria
Karan Thakur: The Ottawa Hospital Research Institute
Alexandre Savard: The Ottawa Hospital Research Institute
Gareth M. Rurak: Carleton University
Marie-Ève Tremblay: University of Victoria
Natalina Salmaso: Carleton University
Luciano da F. Costa: University of São Paulo, São Carlos Institute of Physics, FCM-USP
Gianfilippo Coppola: Yale School of Medicine, Dept. of Pathology
Baptiste Lacoste: The Ottawa Hospital Research Institute

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract Astrocytes are intimately linked with brain blood vessels, an essential relationship for neuronal function. However, astroglial factors driving these physical and functional associations during postnatal brain development have yet to be identified. By characterizing structural and transcriptional changes in mouse cortical astrocytes during the first two postnatal weeks, we find that high-mobility group box 1 (Hmgb1), normally upregulated with injury and involved in adult cerebrovascular repair, is highly expressed in astrocytes at birth and then decreases rapidly. Astrocyte-selective ablation of Hmgb1 at birth affects astrocyte morphology and endfoot placement, alters distribution of endfoot proteins connexin43 and aquaporin-4, induces transcriptional changes in astrocytes related to cytoskeleton remodeling, and profoundly disrupts endothelial ultrastructure. While lack of astroglial Hmgb1 does not affect the blood-brain barrier or angiogenesis postnatally, it impairs neurovascular coupling and behavior in adult mice. These findings identify astroglial Hmgb1 as an important player in postnatal gliovascular maturation.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-40682-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40682-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-40682-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().