Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD

Martin Grashei, Pascal Wodtke, Jason G. Skinner, Sandra Sühnel, Nadine Setzer, Thomas Metzler, Sebastian Gulde, Mihyun Park, Daniela Witt, Hermine Mohr, Christian Hundshammer, Nicole Strittmatter, Natalia S. Pellegata, Katja Steiger and Franz Schilling ()
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Martin Grashei: Technical University of Munich
Pascal Wodtke: Technical University of Munich
Jason G. Skinner: Technical University of Munich
Sandra Sühnel: Technical University of Munich
Nadine Setzer: Technical University of Munich
Thomas Metzler: Technical University of Munich
Sebastian Gulde: Helmholtz Zentrum München
Mihyun Park: Technical University of Munich
Daniela Witt: Technical University of Munich
Hermine Mohr: Helmholtz Zentrum München
Christian Hundshammer: Technical University of Munich
Nicole Strittmatter: Technical University of Munich
Natalia S. Pellegata: Helmholtz Zentrum München
Katja Steiger: Technical University of Munich
Franz Schilling: Technical University of Munich

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T1 of two minutes at 1 T, high pH sensitivity of up to 1.9 ppm per pH unit and suitability of using the C1-label as internal frequency reference enables pH imaging in vivo of three pH compartments in healthy rat kidneys. Spectrally selective targeting of both 13C-resonances enables simultaneous imaging of perfusion and filtration in 3D and pH in 2D within one minute to quantify renal blood flow, glomerular filtration rates and renal pH in healthy and hydronephrotic kidneys with superior sensitivity compared to clinical routine methods. Imaging multiple biomarkers within a single session renders [1,5-13C2]Z-OMPD a promising new hyperpolarized agent for oncology and nephrology.

Date: 2023
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DOI: 10.1038/s41467-023-40747-3

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