Thin, soft, wearable system for continuous wireless monitoring of artery blood pressure

Jian Li, Huiling Jia, Jingkun Zhou, Xingcan Huang, Long Xu, Shengxin Jia, Zhan Gao, Kuanming Yao, Dengfeng Li, Binbin Zhang, Yiming Liu, Ya Huang, Yue Hu, Guangyao Zhao, Zitong Xu, Jiyu Li, Chun Ki Yiu, Yuyu Gao, Mengge Wu, Yanli Jiao, Qiang Zhang, Xuecheng Tai, Raymond H. Chan, Yuanting Zhang, Xiaohui Ma () and Xinge Yu ()
Additional contact information
Jian Li: City University of Hong Kong
Huiling Jia: City University of Hong Kong
Jingkun Zhou: City University of Hong Kong
Xingcan Huang: City University of Hong Kong
Long Xu: Jilin University
Shengxin Jia: City University of Hong Kong
Zhan Gao: City University of Hong Kong
Kuanming Yao: City University of Hong Kong
Dengfeng Li: City University of Hong Kong
Binbin Zhang: City University of Hong Kong
Yiming Liu: City University of Hong Kong
Ya Huang: City University of Hong Kong
Yue Hu: City University of Hong Kong
Guangyao Zhao: City University of Hong Kong
Zitong Xu: City University of Hong Kong
Jiyu Li: City University of Hong Kong
Chun Ki Yiu: City University of Hong Kong
Yuyu Gao: City University of Hong Kong
Mengge Wu: City University of Hong Kong
Yanli Jiao: City University of Hong Kong
Qiang Zhang: City University of Hong Kong
Xuecheng Tai: Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE)
Raymond H. Chan: City University of Hong Kong
Yuanting Zhang: City University of Hong Kong
Xiaohui Ma: The first medical center of Chinese PLA General Hospital
Xinge Yu: City University of Hong Kong

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Continuous monitoring of arterial blood pressure (BP) outside of a clinical setting is crucial for preventing and diagnosing hypertension related diseases. However, current continuous BP monitoring instruments suffer from either bulky systems or poor user-device interfacial performance, hampering their applications in continuous BP monitoring. Here, we report a thin, soft, miniaturized system (TSMS) that combines a conformal piezoelectric sensor array, an active pressure adaptation unit, a signal processing module, and an advanced machine learning method, to allow real wearable, continuous wireless monitoring of ambulatory artery BP. By optimizing the materials selection, control/sampling strategy, and system integration, the TSMS exhibits improved interfacial performance while maintaining Grade A level measurement accuracy. Initial trials on 87 volunteers and clinical tracking of two hypertension individuals prove the capability of the TSMS as a reliable BP measurement product, and its feasibility and practical usability in precise BP control and personalized diagnosis schemes development.

Date: 2023
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DOI: 10.1038/s41467-023-40763-3

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