A nuclear receptor HR96-related gene underlies large trans-driven differences in detoxification gene expression in a generalist herbivore

Meiyuan Ji, Marilou Vandenhole, Berdien Beer, Sander Rouck, Ernesto Villacis-Perez, René Feyereisen, Richard M. Clark () and Thomas Leeuwen ()
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Meiyuan Ji: University of Utah
Marilou Vandenhole: Ghent University
Berdien Beer: Ghent University
Sander Rouck: Ghent University
Ernesto Villacis-Perez: Ghent University
René Feyereisen: Ghent University
Richard M. Clark: University of Utah
Thomas Leeuwen: Ghent University

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract The role, magnitude, and molecular nature of trans-driven expression variation underlying the upregulation of detoxification genes in pesticide resistant arthropod populations has remained enigmatic. In this study, we performed expression quantitative trait locus (eQTL) mapping (n = 458) between a pesticide resistant and a susceptible strain of the generalist herbivore and crop pest Tetranychus urticae. We found that a single trans eQTL hotspot controlled large differences in the expression of a subset of genes in different detoxification gene families, as well as other genes associated with host plant use. As established by additional genetic approaches including RNAi gene knockdown, a duplicated gene with a nuclear hormone receptor HR96-related ligand-binding domain was identified as causal for the expression differences between strains. The presence of a large family of HR96-related genes in T. urticae may enable modular control of detoxification and host plant use genes, facilitating this species’ known and rapid evolution to diverse pesticides and host plants.

Date: 2023
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DOI: 10.1038/s41467-023-40778-w

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