CRUSTY: a versatile web platform for the rapid analysis and visualization of high-dimensional flow cytometry data

Simone Puccio (), Giorgio Grillo, Giorgia Alvisi, Caterina Scirgolea, Giovanni Galletti, Emilia Maria Cristina Mazza, Arianna Consiglio, Gabriele De Simone, Flavio Licciulli and Enrico Lugli ()
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Simone Puccio: IRCCS Humanitas Research Hospital
Giorgio Grillo: National Research Council
Giorgia Alvisi: IRCCS Humanitas Research Hospital
Caterina Scirgolea: IRCCS Humanitas Research Hospital
Giovanni Galletti: IRCCS Humanitas Research Hospital
Emilia Maria Cristina Mazza: IRCCS Humanitas Research Hospital
Arianna Consiglio: National Research Council
Gabriele De Simone: Flow Cytometry Core, IRCCS Humanitas Research Hospital
Flavio Licciulli: National Research Council
Enrico Lugli: IRCCS Humanitas Research Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-7

Abstract: Abstract Flow cytometry (FCM) can investigate dozens of parameters from millions of cells and hundreds of specimens in a short time and at a reasonable cost, but the amount of data that is generated is considerable. Computational approaches are useful to identify novel subpopulations and molecular biomarkers, but generally require deep expertize in bioinformatics and the use of different platforms. To overcome these limitations, we introduce CRUSTY, an interactive, user-friendly webtool incorporating the most popular algorithms for FCM data analysis, and capable of visualizing graphical and tabular results and automatically generating publication-quality figures within minutes. CRUSTY also hosts an interactive interface for the exploration of results in real time. Thus, CRUSTY enables a large number of users to mine complex datasets and reduce the time required for data exploration and interpretation. CRUSTY is accessible at https://crusty.humanitas.it/ .

Date: 2023
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DOI: 10.1038/s41467-023-40790-0

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